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    Good quote: On consumerism
    • Its tendency always, on the one side, to create disposable time, on the other, to convert it into surplus labour.

      Karl Marx

    1 comment 2 comments Vitaliy_KiselevAugust 26Last reply - August 26 by Vitaliy_Kiselev Subscribe to this blog
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    Being average
    • image

      All day, every day, we are flooded with the truly extraordinary. The best of the best. The worst of the worst. The greatest physical feats. The funniest jokes. The most upsetting news. The scariest threats. Non-stop.

      Our lives today are filled with information coming from the extremes of the bell curve, because in the media that’s what gets eyeballs and the eyeballs bring dollars. That’s it. Yet the vast majority of life continues to reside in the middle.

    1 comment 2 comments Vitaliy_KiselevAugust 25Last reply - August 27 by Tailschao Subscribe to this blog
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    1 comment 2 comments Vitaliy_KiselevAugust 25Last reply - August 25 by Manu4Vendetta Subscribe to this blog
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    Cannabis makes rats lazy
    • Background: Acceptance of cannabis use is growing. However, prolonged use is associated with diminished psychosocial outcomes, potentially mediated by drug-induced cognitive impairments. Δ9-Tetrahydrocannabinol (THC) is the main psychoactive ingredient in cannabis, yet other phytocannabinoids in the plant, such as cannabidiol (CBD), have unique properties. Given that CBD can modulate the undesirable effects of THC, therapeutic agents, such as nabiximols, contain higher CBD:THC ratios than illicit marijuana. We tested the hypothesis that THC impairs a relevant cognitive function for long-term success, namely willingness to exert cognitive effort for greater rewards, and that CBD could attenuate such decision-making impairments.

      Methods: Male Long–Evans rats (n = 29) performing the rat cognitive effort task (rCET) received acute THC and CBD, independently and concurrently, in addition to other cannabinoids. Rats chose between 2 options differing in reward magnitude, but also in the cognitive effort (attentional load) required to obtain them.

      Results: We found that THC decreased choice of hard trials without impairing the animals’ ability to accurately complete them. Strikingly, this impairment was correlated with CB1 receptor density in the medial prefrontal cortex — an area previously implicated in effortful decision-making. In contrast, CBD did not affect choice. Coadministration of 1:1 CBD:THC matching that in nabiximols modestly attenuated the deleterious effects of THC in “slacker” rats. Limitations: Only male rats were investigated, and the THC/CBD coadministration experiment was carried out in a subset of individuals. Conclusion: These findings confirm that THC, but not CBD, selectively impairs decision-making involving cognitive effort costs. However, coadministration of CBD only partially ameliorates such THC-induced dysfunction.

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    Good quote: On deception and learning
    • People always have been the foolish victims of deception and self-deception in politics, and they always will be, until they have learned to seek out the interests of some class or other behind all moral, religious, political and social phrases, declarations and promises.

      V. Lenin.

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