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What do we know about the novel coronavirus?
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  • @kurth

    It is getting old.

    I really wish all this US "patriots" get their guns and start to demand proper masks from their local criminal goverment. As it is now China who is doing their job and ramping masks production.

    It is just one problem with this, this dogs can bark only at China, as it is safe from distance and they'll get big nice kick if they even try to rise their voice againts their owners.

  • @kurth

    Research is very, very bad.

    • First, it is very unclear about statistics of the samples. It had been 2 samples as written (you can't make papaer such way!)?
    • Second, why they used swab for comparison? As samples must be instead real size droples that are on the surface. As all the parts in lab are being utilized, no one just heat them to 60 and tell that all is ok.
    • Third, "two swabs were taken from the kidney cells of an African green monkey which was infected with coronavirus" makes it real strange, as in real life you need autopsy for this. Why it had been made such, may be because mucosal cells does not fit their proposed results?

    So, it is questionable research talking about specific lab conditions.

    In summer heat plays good role (allowing much more water to be evaporated for same amount of air, hence less life for each droplet) but UV play even bigger role.

  • According to the validation analysis of these finds, chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress. Since the ability of chloroquine to inhibit structural proteins is not particularly obvious, the therapeutic effect on different people may be different.

    https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173

  • "Beyond the practical level, managers and employees understand that there is another possibility for how we work – and it is succeeding. Organizations have invested heavily in remote work capabilities. This investment will be something that organizations will want to preserve, whether it's the changes they have made in the corporate culture or changes made by improving and/or implementing technology platforms."

    Hiring can be more flexible in terms of geography, with greater recruitment options as boundaries expand to increasingly remote locations.

    Read - Uber like approach for most workers. Hiring for making specific thing only, work from home, no medical insurance provided. Much smaller hourly rate. Even to get work you will pay to Google and alike for different promotional options.

  • It is small coincidence that in 2002 right before first SARS virus developers managed to make firts fully synthetic virus (assembly virus from synthtic parts using DNA manipulation and DNA to RNA transcription).

    https://jvi.asm.org/content/76/21/11065

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    Can check superb article in Russian on coronaviruses and lab related stuff

    https://habr.com/ru/post/497956/

    In short - imagine that you have lot of open journals with detailed instructions on how to make small DiY thermonuclear bomb, also lot of wirely known online shops sell you parts (including all radioactive ones), another part of shops sell means of delivery (can select tactical, strategic or anything you like). Lot of small firms at the same time are making thermonuclear bombs and some even blast them in small distant cities full of real people (all other do it int he national parts to test on animals) with public goal being "to test possible perception of thermonuclear blast and optimise our response". Looks like absurd? No - this is that we have in applied virusology now. And we do not knwo that happens in closed weaponised segment even.

    The GeneArt Seamless Cloning and Assembly Kit enables the simultaneous and directional cloning of 1 to 4 PCR fragments, consisting of any sequence, into any linearized vector, in a single 30-minute room temperature reaction. The kit contains everything required for the assembly of DNA fragments, and their transformation into E. coli for selection and growth of recombinant vectors.

    • Speed and Ease —Clone up to 4 DNA fragments, with sequence of your choice, simultaneously in a single vector (up to 13 Kb); no restriction digestion, ligation or recombination sites required
    • Precision and Efficiency — Designed to let you clone what you want, where you want, in the orientation you want, and achieve up to 90% correct clones with no extra sequences left behind
    • Vector Flexibility — Use our linear vector or a vector of your choice
    • Free Tools — Design DNA oligos and more with our free web-based interface that walks you step-by-step through your project
    • Diverse Applications — Streamline many synthetic biology and molecular biology techniques through the rapid combination, addition, deletion, or exchange of DNA segments

    In reality we can have soon Nurnberg like trial where up to 50% of leading virusology researches must be present as criminals.

    On the basis of these findings, scientific review panels may deem similar studies building chimeric viruses based on circulating strains too risky to pursue, as increased pathogenicity in mammalian models cannot be excluded. Coupled with restrictions on mouse-adapted strains and the development of monoclonal antibodies using escape mutants, research into CoV emergence and therapeutic efficacy may be severely limited moving forward. Together, these data and restrictions represent a crossroads of GOF research concerns; the potential to prepare for and mitigate future outbreaks must be weighed against the risk of creating more dangerous pathogens. In developing policies moving forward, it is important to consider the value of the data generated by these studies and whether these types of chimeric virus studies warrant further investigation versus the inherent risks involved.

    Most fun part is that fully eradicating natural sites of this viruses (yes, with all the bats!) cost around 1/100 of one year funding for this labs, and will be totally safe. But instead of eradicating virus sources they protected all this sites breaking any normal human logic (simple to understand to anyone until you are some brean dead nazist).

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  • Galveston lab taking part in teaching Wuhan lab personell

    This info had been deleted from public.

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    https://web.archive.org/web/20200404101918/http:/english.whiov.cas.cn/Newsletter2016/201811/P020181130367907308937.pdf

  • that's what I've said, since the first day....all research in most universities around the world is defense dept funded. Galveston is Univ of Texas Med school but UT is the 2nd richest university in the USa below Harvard, which probably makes it the 2nd richest in the world. Millions of dollars in grants every year from defense. MIT....totally in on dept of Defense funding. UofC Berkeley ....big into defense funding. UofC has lawrence livermore....univ of new mexico has sandia labs , UT has Electromechanics ...etc etc. But problem is greater than who pays their checks. Modern science is a moral vacuum. The only thing important is solving the problem. We've even transcended Oppenheimer's guilt. If it's not a virus that wipes out humanity, it'll be a black hole created at CERN. This won't end well. The ancient greeks knew.

  • @kurth

    Do not worry, this guys won't make any black holes, same as they can't make any thermouclear reactor.

    Lack of moral is normal, as you have normal capitalist citizens who only want money (and also good position in hierarchy to warrant money in long term).

  • It is expected that from 50% up to 80% of banks (worldwide) won't make it past 2020.

    Some of the biggest banks will be bailed out.

  • How media propaganda works

    • Japan that mostly lacks media hysteria - only 7% people fully agree to accept self isolation measures and restriction for their freedoms, 42% absolutely do not agree to accept any form of this
    • Mordor - 68% agree to same (had been 60% week ago and below 40% one month ago), 28% do not agree.
    • US - 69%, 25% do not agree.

    For now all media work very good and are able to control most of population.

    Yet all of them expect new wave of issues, as any small gatherings and sharing of opinions can turn things upside down.

  • Doctors in Japan have warned that the country's medical system could collapse amid a wave of new coronavirus cases.

    Emergency rooms have been unable to treat some patients with serious health conditions due to the extra burden caused by the virus, officials say. One ambulance carrying a patient with coronavirus symptoms was turned away by 80 hospitals before he could be seen.

    Japan, which initially appeared to have the virus under control, passed 10,000 confirmed cases on Saturday.

  • Lex Fridman , Research in human-centered AI, deep learning, autonomous vehicles & robotics at MIT and beyond. Also, I teach courses on deep learning.

    The coronavirus pandemic is a global crisis, but it is also a moment that unites us, that reveals the strength of our community, the human capacity to be compassionate to each other and to work hard in the face of danger. In this video I describe what, to me, might be 7 levels of attack on our society and how we can fight back. For each level, I describe our pain, our challenge, and our hope for a positive future on the other side.

  • Economic shutdown index

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    https://spydell.livejournal.com/682895.html

    Note the sync between countries (despite completely different number of infected at the time).

    Also note Taiwan performance, as it is core entity for whole plan due to huge manufacturing of servers, chips and similar things.

    Author expects that around 100x more people will die due to artificial economic collapse compared to virus casualities.

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  • @Vitaliy....righttt...and they didn't make atomic weapons either .... @jleo....this guys got too much time on his hands and is too inexperienced . He's also responsible for tesla's self driving capacity, which should warn. It's limited propaganda. The verbosity of youth. But his equation should be further resolved . 1 & 2 are one thing....personal survival against the threat. 3,4 & 5 are another thing, social survival with absolute need for societal defense and learn to prevent similar events . 6 & 7 are moral survival , the moral tools we use to survive and defend against the attack, surmise fault, and deliver punishment. He slightly referred to "conspiracy theory", which was in a derogatory manner. I think the first criteria should be to judge the event as natural or man-made. There's enough information available to preview a claim that the viruses escape into the human domain wasn't by an animal human vector. That means, there's need of an investigation into culpability. Anyone who doesn't phrase everything they know in that light, is spewing propaganda.

  • The big question nobody's answering is....apparently large percentage of the population are infected w/o symptoms, and enough people are reinfecting after being cured that question the fundamental idea of what does infected and cured really mean. Does the virus activate or reactivate inside unknowing host by some triggering event at some later date ? And there was this conspiracy thread on reddit.....worth reading the whole ID : 7bgvDDu6 thread .... https://www.reddit.com/r/CoronavirusFOS/comments/g3euzw/a_creepy_post_by_an_anon_who_claimed_to_be_a_p4/

  • and what happened to the masks and why we're forced to reuse them....

  • In light of the attack from the Invisible Enemy, as well as the need to protect the jobs of our GREAT American Citizens, I will be signing an Executive Order to temporarily suspend immigration into the United States!

    Big shifts coming.

  • Facebook said on Monday that it was banning users from organising “events that defy government’s guidance on social distancing”. The company’s decision to selectively enforce state public health orders came amid a spate of rallies protesting against statewide stay-at-home orders in cities cross the US, and it drew condemnation from rightwing supporters of the protest movement, Donald Trump Jr, and the American Civil Liberties Union (ACLU).

    This is no longer borderline. This guys really need some physical push already.

  • @kurth

    Video is from Anti Chinese channel with very bad reputation.

    If you ask me - reality is different, huge number of Chinese companies started to make protection equipment, including good masks. Of course many want to profit, but US and EU companies are mostly sitting doing nothing. I talked to few in private and they just think that it is better to sit on money and don't risk. All of them are are sure that goverments will print more money and will give them, just for their existence.

  • @Vitaliy ....o...one of those with a very bad rep! It's falun gong, which obviously means it's anti-chinese...but that doesn't mean it's not the truth. Go to tibet and ask them about chinese policy...and then go to nepal and ask tibetan refugees the same question. I'll believe the tibetan refugees. Google china supply chain crisis. There's lots of articles. Yep...they'll be big changes concerning china supply chains, esp concerning the medical and pharmaceutical sources. These will become national security issues.

  • @kurth

    Right now main national security issue for US is goverment and biggest local capitalists, both of them act similar to enemies of the state.

    Of course it is safe and nicer to try ot get loupe and find some issues in China. :-)