The X299 looks like an awesome workstation. My X99 workstation has been great no issues at all but time for an upgrade. The Asus X299 has everything I want in a motherboard along with Thunderbolt 3. Hopefully I can run OSX High Sierra on this. OSX Sierra works great with my X99 workstation. I noticed on TonyMac that they are already running OSX High Sierra on an Asus motherboard so I am pretty sure it will work. I am having a very difficult time abandoning the OSX operating system as you can tell. I actually never boot into Windows unless I need to update firmware on my Godox flashes and Monolights so I guess Windows 10 Pro comes in handy for something... LOL

TonyMac X299 Workstation https://www.tonymacx86.com/threads/skylake-x-x299-live-the-future-now-on-macos-high-sierra-10-13-successful-build-extended-guide.229353/